Maintaining the first edition's unique parallel to the strategy used by pathologists and pulmonologists to arrive at a patient's diagnosis in daily practice, Diagnostic Pulmonary Pathology starts with the patient and their biopsy findings, directing the pathologist or clinician to the proper diagnosis. With many advances in pulmonary pathology, radiology, and pulmonary medicine, this new edition provides thorough updates in: progress in classification and diagnosis of interstitial lung diseases evolution of our understanding of pre-neoplastic lesions technology in histopathology molecular pathology thoracic radiology Written by contributing doctors who are at the forefront of recent advancements, Diagnostic Pulmonary Pathology: is organized based on how the patient should be approached, and the patient's own projections, signs, symptoms, and disease provides new imaging techniques and molecular diagnostic tests investigates the new classification schemes, i.e. classification and terminology for lung neoplasms, pulmonary hypertension, and lung transplant rejection gives coverage of the merging of radiology and pathology, including molecular imaging

Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series the basic science and the technology is integrated with the medical perspective and clinical application. Each book in the series is divided according to neoplastic and non-neoplastic diseases for each of the organ systems traditionally associated with medical subspecialties.

Each book in the series is organized to provide (1) a succinct background of the essential terminology, concepts and technology of molecular biology, (2) an overview of the broad application of molecular biology principles to disease and (3) specific application of molecular pathology to the pathogenesis, diagnosis and treatment of neoplastic and non-neoplastic diseases specific to each organ system. These broad section topics will be broken down into succinct chapters, averaging about 15 to 20 pages each, to cover a very specific disease entity. The chapters will be written by established authorities on the specific topic from academic centers around the world. In one book, diverse subjects are included that the reader would have to pursue from multiple sources in order to have a clear understanding of the molecular pathogenesis, diagnosis and treatment of specific diseases. Attempting to hunt for the full information from basic concept to specific applications for a disease from the varied sources is time-consuming and frustrating. By providing this quick and user-friendly reference, understanding and application of this rapidly growing field is made more accessible to both expert and generalist alike.

As books that bridge the gap between basic science and clinical understanding and practice, the Molecular Pathology Series serves the basic scientist, the clinical researcher and the practicing physician or other health care provider who require more understanding of the application of basic research to patient care, from "bench to bedside." This series is unique and an invaluable resource. These books will be indispensable to physicians and health care providers in multiple disciplines as noted above, to residents and fellows in these multiple disciplines as well as their teaching institutions and to researchers who increasingly must justify the clinical implications of their research.

Frozen sections are performed for the purpose of rapid diagnosis while a patient is undergoing surgery, usually under general anesthesia, as a basis for making immediate treatment decisions. Therefore, frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly and a crucial determination for the patient and surgeon. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissues that can be examined in a more leisurely fashion. Most standard pathology textbooks, both general and subspecialty, largely ignore the topic of frozen section. Few textbooks have ever focused exclusively on frozen section diagnosis and those textbooks that have done so are now out-of-date and have limited numbers of black and white figures. None has emphasized the education of the surgeon in terms of frozen section benefits, limitations or proper utilization.

The Frozen Section Library series will provide convenient, user-friendly handbooks for each organ system to expedite use in the hurried frozen section situation. These books will be small and light-weight, copiously color illustrated with images of actual frozen sections, highlighting pitfalls, artifacts and differential diagnosis. These books will also include perspectives for the surgeon and for communication with the surgeon and suggest ancillary procedures (for example, when to take tissue for microbiology cultures). Each 5 X 8 book is estimated to be about 200 to 250 pages in toto with 100 to 150 color figures each.

As a handbook for practicing pathologists, these books will be indispensable aids to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Problems, such as differentiation of benign processes from malignant neoplasms which may be more difficult on frozen section than permanent section and which have a serious impact on the surgeon s immediate treatment decisions, will be emphasized. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts will be readily accessible to the users of the handbooks. A series of concise, easy-to-use, well-illustrated handbooks alleviates the often frustrating and time-consuming, sometimes futile, process of searching through bulky textbooks that are unlikely to illustrate or discuss pathologic diagnoses from the perspective of frozen

sections in the first place. Tables and charts will provide guidance for differential diagnosis of various histologic patterns.

The advantages of a series of organ-specific handbooks, in addition to the ease-of-use and manageable size, is that (1) it allows more comprehensive coverage of more diagnoses, both common and rare, than a single volume that tries to highlight a limited number of diagnoses for each organ and (2) it allows more detailed insight by permitting experienced authorities to emphasize the peculiarities of frozen section for each organ system. Although some differences in practice of frozen section exist between different institutions, such as differing policies regarding whether or not to perform frozen section on specific types of specimens, these differences are generally not significant and can be discussed ( an organ-specific handbook by an expert in that organ system permits more opportunity for this type of discussion). Touch preparations, which are used for some organs such as central nervous system or thyroid more often than others, will be appropriately emphasized and illustrated according to the need for each specific organ.

This series will be highly valuable to practicing surgical pathologists, both community and academic, and to pathology residents and fellows. The perspectives provided will also be valuable to surgeons and especially to surgery residents and fellows who must answer questions about pathology and frozen section on their board examinations. These handbooks will be easily portable by the individual but it is envisioned that many departments will want to also keep a series readily available in the frozen section laboratory. "

Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care.

The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine.

Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Frozen sections are performed for the purpose of rapid diagnosis while a patient is undergoing surgery, usually under general anesthesia, as a basis for making immediate treatment decisions. Therefore, frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly and a crucial determination for the patient and surgeon. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissues that can be examined in a more leisurely fashion. Most standard pathology textbooks, both general and subspecialty, largely ignore the topic of frozen section. Few textbooks have ever focused exclusively on frozen section diagnosis and those textbooks that have done so are now out-of-date and have limited numbers of black and white figures. None has emphasized the education of the surgeon in terms of frozen section benefits, limitations or proper utilization.

The Frozen Section Library series will provide convenient, user-friendly handbooks for each organ system to expedite use in the hurried frozen section situation. These books will be small and light-weight, copiously color illustrated with images of actual frozen sections, highlighting pitfalls, artifacts and differential diagnosis. These books will also include perspectives for the surgeon and for communication with the surgeon and suggest ancillary procedures (for example, when to take tissue for microbiology cultures). Each 5 X 8 book is estimated to be about 200 to 250 pages in toto with 100 to 150 color figures each.

As a handbook for practicing pathologists, these books will be indispensable aids to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Problems, such as differentiation of benign processes from malignant neoplasms which may be more difficult on frozen section than permanent section and which have a serious impact on the surgeon s immediate treatment decisions, will be emphasized. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts will be readily accessible to the users of the handbooks. A series of concise, easy-to-use, well-illustrated handbooks alleviates the often frustrating and time-consuming, sometimes futile, process of searching through bulky textbooks that are unlikely to illustrate or discuss pathologic diagnoses from the perspective of frozen sections in the first place. Tables and charts will provide guidance for differential diagnosis of various histologic patterns.

The advantages of a series of organ-specific handbooks, in addition to the ease-of-use and manageable size, is that (1) it allows more comprehensive coverage of more diagnoses, both common and rare, than a single volume that tries to highlight a limited number of diagnoses for each organ and (2) it allows more detailed insight by permitting experienced authorities to emphasize the peculiarities of frozen section for each organ system. Although some differences in practice of frozen section exist between different institutions, such as differing policies regarding whether or not to perform frozen section on specific types of specimens, these differences are generally not significant and can be discussed ( an organ-specific handbook by an expert in that organ system permits more opportunity for this type of discussion). Touch preparations, which are used for some organs such as central nervous system or thyroid more often than others, will be appropriately emphasized and illustrated according to the need for each specific organ.

This series will be highly valuable to practicing surgical pathologists, both community and academic, and to pathology residents and fellows. The perspectives provided will also be valuable to surgeons and especially to surgery residents and fellows who must answer questions about pathology and frozen section on their board examinations. These handbooks will be easily portable by the individual but it is envisioned that many departments will want to also keep a series readily available in the frozen section laboratory."

Cellular and Molecular Pathology of the Liver is extensive, complex and ranges from the understanding the basic molecular mechanisms that dictate everything from liver homeostasis to liver disease. Molecular Pathology of the liver is complicated due to some of the important functions inherent and unique to the Liver, including its innate ability to regenerate and the multitude of functions it plays for the wellbeing of an organism. With all this in mind, Molecular Pathology of Liver Diseases is organized in different sections, which will coherently and cohesively present the molecular basis of hepatic physiology and pathology. The first two sections are key to understanding the liver anatomy and physiology at a cellular level and go on to define the molecular mechanics in various liver cell types. These sections also cover the existing paradigms in liver development, regeneration and growth. The next section is key to understanding the Molecular Pathology unique to liver diseases and associated phenotypes. The final sections are geared towards the existing knowledge of the molecular basis of many common and uncommon liver diseases in both neoplastic and non-neoplastic areas including pathologies associated with intra-hepatic and extra-hepatic biliary tree. Thus, this textbook is a one-stop reference for comprehending the molecular mechanisms of hepatic pathobiology. It is clearly unique in its format, readability and information and thus will be an asset to many in the field of Pathology and other disciplines.

This major work, complete with 150 illustrations, many of them in color, bridges the gap between clinical pulmonary pathology and basic molecular science. Through a highly visual approach that features an abundance of tables and diagrams, the book offers a practical disease-based overview. The first two sections of the volume provide the reader with general concepts, terminology and procedures in molecular pathology. The remainder of the volume is subdivided into neoplastic and non-neoplastic lung diseases with detailed chapters covering the current molecular pathology of specific diseases. The book will be essential reading for pathologists, pulmonologists, thoracic surgeons and other health care providers interested in lung disease.

Frozen sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly for the patient and surgeon. The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario.

Frozen sections of the pancreas are performed to assess resectability, for tissue confirmation and to assess margins. The clinical implications of an accurate frozen section diagnosis are dramatic as far as type and extent of surgery performed. "Frozen Section of the Pancreas" will provide a concise pictorial compendium to facilitate intraoperative consultations on pancreas specimens. The book will be 5x8 and is estimated to be 200-250 pages with 100-150 color figures. This user-friendly handbook will be divided into chapters that emphasize the common questions a pathologist must answer on frozen section examination and will provide guidance for the differential diagnosis of various histologic patterns. The purpose of this book is to aid in the timely frozen section diagnosis of pancreatic lesions by using a broad array of illustrations, which would reinforce one's visual memory, and a condensed text, useful for rapid review of main diagnostic features. Currently, there is no other up-to-date, single-source reference specifically focused on frozen sections of the pancreas.

Entirely re-written and revised with over 1,000 new images, Pulmonary Pathology: An Atlas and Text is a comprehensive, highly illustrated guide to diagnoses in pulmonary pathology, including tumors and lymphomas. The book-titled Color Atlas and Text of Pulmonary Pathology in earlier editions - combines highly detailed photographs and illustrations with concise, bulleted text so you can quickly grasp the information you need to make accurate diagnoses. New information on diagnosing lung diseases, plus new WHO classifications, American Thoracic Society classifications of non-neoplastic diseases, new entities and infections, and technological advancements. Packed with nearly1,200 images, figures, and tables, many of them new with this edition. Organized into individual diagnoses, accompanied by concise, bulleted descriptions. Ideal for surgical pathologists already in practice, as well as pathology residents and fellows. Addresses the expanded role of the pathologist in treating patients. Enrich Your eBook Reading Experience with Enhanced Video, Audio and Interactive Capabilities! Read directly on your preferred device(s ), such as computer, tablet, or smartphone Easily convert to audiobook , powering your content with natural language text-to-speech Adapt for unique reading needs , supporting learning disabilities, visual/auditory impairments, second-language or literacy challenges, and more

Intraoperative frozen section interpretation is the base for treatment for the patient within the operating room. It requires immediate answer for the surgeon s specific question and the subsequent consequences are frequently irreversible. The pathologist should be very familiar with the related differential diagnosis of the involved organ. Additionally, the pathologist needs to know many pitfalls and freezing artifacts in each organ and the clinical implications each diagnosis may result in. Frozen Section Library: Head and Neck will provide a convenient, user-friendly handbook to expedite use when performing intraoperative consultations on head and neck specimens. This book will be 5 X 8 and is estimated to be about 200 to 250 pages in toto with 100 to 150 color figures. An organ and clinical scenario based approach will be used in this book. This book will be divided into chapters based on the organs and anatomic locations. Within the chapter, a consistent format with the critical issues as a focus will be used including the frequently encountered clinical scenarios and the specific questions from the surgeons, frequent diagnostic considerations and their major diagnostic criteria with associated diagnostic pearls, artifacts and pitfalls and how to avoid them. Common and practical problems including reactive atypia versus carcinoma in salivary glands, resection margins in tongue and laryngectomy specimens, small blue cell tumors in the base of the skull, a primary lesion versus a metastatic squamous carcinoma in the neck, etc. will be illustrated with color pictures and accompanied legend. As a handbook for practicing pathologists, this book will be an indispensable aid to diagnosis and avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts will be readily accessible to the users of this handbook. Tables and charts will provide guidance for differential diagnosis of various histological patterns. This book will be highly valuable to practicing surgical pathologists, both community and academic, and to pathology residents and fellows. The perspectives provided will also be valuable to head and neck surgeons and especially to surgery residents and head and neck surgery fellows who must answer questions about pathology and frozen section on their board examinations. This handbook will be easily portable by the individual but it is envisioned that many departments will want to also keep copies readily available in the frozen section laboratory."

Frozen section of Neuropathology-related cases is performed while the patient is undergoing surgery. Intraoperative consultation is used to help guide intraoperative management of the case and to ensure that adequate and appropriate tissue has been obtained for purposes of making an accurate final diagnosis. Frozen section diagnosis is often a highly demanding situation for the pathologist, who must render a diagnosis quickly and provide sound guidance and advice. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissue that can be examined in a more leisurely fashion. Most standard pathology textbooks focus primarily on permanent section material and largely ignore the topic of frozen section. The purpose of this volume is to add to the Frozen Section Library series and provide a convenient, user friendly handbook to assist in the evaluation of central nervous system related frozen sections. It provides a useful reference, organized around differential diagnoses, primarily by location in the central nervous system. The text will be illustrated with color pictures and include tables as appropriate. This text provides a valuable tool for the practicing surgical pathologist both in community and in academic centers as well as pathology residents and fellows in training when confronted with Neuropathology frozen section.

The past two decades have seen an ever accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Mole- lar diagnostics, molecular targeted therapy, and genetic therapy are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, medical oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical inves- gators, pathologists and medical laboratory directors, and radiologists require a basic understanding of the fundamentals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical setting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice.

This book covers the complete field of pulmonary pathology - neoplastic and non-neoplastic - from Acinic cell tumor in the lung to Wegener`s Granulomatosis. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.

Maintaining the first edition s unique parallel to the strategy used by pathologists and pulmonologists to arrive at a patient s diagnosis in daily practice, Diagnostic Pulmonary Pathology starts with the patient and their biopsy findings, directing the pathologist or clinician to the proper diagnosis. With many advances in pulmonary pathology, radiology, and pulmonary medicine, this new edition provides thorough updates in:

• progress in classification and diagnosis of interstitial lung diseases
• evolution of our understanding of pre-neoplastic lesions
• technology in histopathology
• molecular pathology
• thoracic radiology

Written by contributing doctors who are at the forefront of recent advancements, Diagnostic Pulmonary Pathology

• is organized based on how the patient should be approached, and the patient s own projections, signs, symptoms, and disease
• provides new imaging techniques and molecular diagnostic tests
• investigates the new classification schemes, i.e. classification and terminology for lung neoplasms, pulmonary hypertension, and lung transplant rejection
• gives coverage of the merging of radiology and pathology, including molecular imaging